Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) sprG-sprF/-
Location 935785..936011 Replicon chromosome
Accession NZ_CP121204
Organism Staphylococcus aureus strain SA0907

Toxin (Protein)


Gene name SprG2 Uniprot ID A0A0E0VS87
Locus tag P7F77_RS04595 Protein ID WP_000253688.1
Coordinates 935785..935892 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprF2
Locus tag -
Coordinates 935945..936011 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7F77_RS04575 (931046) 931046..934726 + 3681 WP_278043736.1 phage tail spike protein -
P7F77_RS04580 (934713) 934713..934865 + 153 WP_001181555.1 hypothetical protein -
P7F77_RS04585 (934912) 934912..935199 + 288 WP_001040257.1 hypothetical protein -
P7F77_RS04590 (935257) 935257..935553 + 297 WP_000539688.1 DUF2951 domain-containing protein -
P7F77_RS04595 (935785) 935785..935892 + 108 WP_000253688.1 putative holin-like toxin Toxin
- (935945) 935945..936011 - 67 NuclAT_1 - Antitoxin
- (935945) 935945..936011 - 67 NuclAT_1 - Antitoxin
- (935945) 935945..936011 - 67 NuclAT_1 - Antitoxin
- (935945) 935945..936011 - 67 NuclAT_1 - Antitoxin
P7F77_RS04600 (935936) 935936..936040 - 105 Protein_895 hypothetical protein -
P7F77_RS04605 (936091) 936091..936393 + 303 WP_000387656.1 phage holin -
P7F77_RS04610 (936405) 936405..937859 + 1455 WP_103067904.1 N-acetylmuramoyl-L-alanine amidase -
P7F77_RS04615 (938852) 938852..939409 + 558 WP_000528632.1 PBECR4 domain-containing protein -
P7F77_RS04620 (939884) 939884..940023 + 140 Protein_899 hypothetical protein -
P7F77_RS04625 (940029) 940029..940343 - 315 WP_031875045.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - hlb 877115..941748 64633


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-35)


Sequences


Toxin        


Download         Length: 36 a.a.        Molecular weight: 3817.78 Da        Isoelectric Point: 10.4997

>T276063 WP_000253688.1 NZ_CP121204:935785-935892 [Staphylococcus aureus]
VVSIVDALNLMFSFGMFIVTLLGLVIAIVKLSHKK

Download         Length: 108 bp


Antitoxin


Download         Length: 67 bp

>AT276063 NZ_CP121204:c936011-935945 [Staphylococcus aureus]
ATAAATAGAAAAAGGGCAACATGCGGAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E0VS87


Antitoxin

Download structure file

References