276022

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2982464..2983299 Replicon chromosome
Accession NZ_CP121189
Organism Salmonella enterica subsp. enterica serovar Indiana strain S1467

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7W4PV54
Locus tag P6164_RS14730 Protein ID WP_000854821.1
Coordinates 2982464..2982841 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A6H2GGB7
Locus tag P6164_RS14735 Protein ID WP_001285390.1
Coordinates 2982931..2983299 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6164_RS14690 (2977724) 2977724..2978206 - 483 WP_001546652.1 DUF1097 domain-containing protein -
P6164_RS14695 (2978307) 2978307..2978861 - 555 WP_001001883.1 molecular chaperone -
P6164_RS14700 (2978885) 2978885..2979622 - 738 WP_000283643.1 phosphatase -
P6164_RS14705 (2979707) 2979707..2980645 - 939 WP_000402552.1 glyoxylate/hydroxypyruvate reductase GhrA -
P6164_RS14715 (2981118) 2981118..2981960 - 843 WP_072643849.1 DUF4942 domain-containing protein -
P6164_RS14720 (2982045) 2982045..2982242 - 198 WP_023563519.1 DUF957 domain-containing protein -
P6164_RS14725 (2982270) 2982270..2982467 - 198 Protein_2888 DUF5983 family protein -
P6164_RS14730 (2982464) 2982464..2982841 - 378 WP_000854821.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
P6164_RS14735 (2982931) 2982931..2983299 - 369 WP_001285390.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
P6164_RS14740 (2983349) 2983349..2983999 - 651 WP_113387941.1 antitoxin of toxin-antitoxin stability system -
P6164_RS14745 (2984012) 2984012..2984233 - 222 WP_001544501.1 DUF987 domain-containing protein -
P6164_RS14750 (2984302) 2984302..2984778 - 477 WP_001186742.1 RadC family protein -
P6164_RS14755 (2984793) 2984793..2985278 - 486 WP_113387942.1 antirestriction protein -
P6164_RS14760 (2985369) 2985369..2986187 - 819 WP_001234702.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2977158..2977616 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13930.95 Da        Isoelectric Point: 8.5163

>T276022 WP_000854821.1 NZ_CP121189:c2982841-2982464 [Salmonella enterica subsp. enterica serovar Indiana]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.52 Da        Isoelectric Point: 5.9618

>AT276022 WP_001285390.1 NZ_CP121189:c2983299-2982931 [Salmonella enterica subsp. enterica serovar Indiana]
VSDTFHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W4PV54

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GGB7

References