Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1501351..1501864 Replicon chromosome
Accession NZ_CP121160
Organism Streptococcus agalactiae strain S5

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag P8R99_RS08000 Protein ID WP_000481712.1
Coordinates 1501610..1501864 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag P8R99_RS07995 Protein ID WP_000387490.1
Coordinates 1501351..1501617 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8R99_RS07960 1497617..1498849 + 1233 WP_000338840.1 replication initiation factor domain-containing protein -
P8R99_RS07965 1498865..1499242 + 378 WP_000287184.1 hypothetical protein -
P8R99_RS07970 1499226..1499441 + 216 WP_001897988.1 helix-turn-helix transcriptional regulator -
P8R99_RS07975 1499434..1499787 + 354 WP_000571928.1 helix-turn-helix transcriptional regulator -
P8R99_RS07980 1499919..1500191 + 273 WP_000072642.1 hypothetical protein -
P8R99_RS07985 1500243..1500725 + 483 WP_000383282.1 antirestriction protein ArdA -
P8R99_RS07990 1500733..1501206 + 474 WP_000560386.1 hypothetical protein -
P8R99_RS07995 1501351..1501617 + 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
P8R99_RS08000 1501610..1501864 + 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
P8R99_RS08005 1501917..1502870 + 954 WP_000565542.1 conjugal transfer protein -
P8R99_RS08010 1502890..1503156 + 267 WP_001055036.1 hypothetical protein -
P8R99_RS08015 1503160..1503570 + 411 WP_000390748.1 conjugal transfer protein -
P8R99_RS08020 1503591..1506092 + 2502 WP_000239405.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1492167..1515059 22892


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T276012 WP_000481712.1 NZ_CP121160:1501610-1501864 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT276012 WP_000387490.1 NZ_CP121160:1501351-1501617 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References