Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3720696..3721237 Replicon chromosome
Accession NZ_CP121157
Organism Escherichia coli strain E89

Toxin (Protein)


Gene name yafQ Uniprot ID Q32JN3
Locus tag P6H86_RS18430 Protein ID WP_000615980.1
Coordinates 3720959..3721237 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag P6H86_RS18425 Protein ID WP_000729707.1
Coordinates 3720696..3720956 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H86_RS18405 (3716362) 3716362..3717147 - 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -
P6H86_RS18410 (3717119) 3717119..3718831 + 1713 Protein_3601 flagellar biosynthesis protein FlhA -
P6H86_RS18415 (3719064) 3719064..3719561 - 498 WP_000006245.1 REP-associated tyrosine transposase RayT -
P6H86_RS18420 (3719737) 3719737..3720510 - 774 WP_000543885.1 C40 family peptidase -
P6H86_RS18425 (3720696) 3720696..3720956 + 261 WP_000729707.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
P6H86_RS18430 (3720959) 3720959..3721237 + 279 WP_000615980.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
P6H86_RS18435 (3721393) 3721393..3722133 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
P6H86_RS18440 (3722104) 3722104..3722871 - 768 WP_000333380.1 class II glutamine amidotransferase -
P6H86_RS18445 (3723077) 3723077..3723655 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T275994 WP_000615980.1 NZ_CP121157:3720959-3721237 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWLLIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9421.80 Da        Isoelectric Point: 5.0758

>AT275994 WP_000729707.1 NZ_CP121157:3720696-3720956 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKTKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NH48

Antitoxin

Source ID Structure

References