Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2410570..2411132 Replicon chromosome
Accession NZ_CP121153
Organism Escherichia coli strain E57

Toxin (Protein)


Gene name higB Uniprot ID L4J948
Locus tag P6H84_RS11650 Protein ID WP_000605676.1
Coordinates 2410854..2411132 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag P6H84_RS11645 Protein ID WP_000781370.1
Coordinates 2410570..2410854 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H84_RS11630 (2405929) 2405929..2408976 + 3048 WP_012311994.1 formate dehydrogenase-N subunit alpha -
P6H84_RS11635 (2408989) 2408989..2409873 + 885 WP_001240582.1 formate dehydrogenase N subunit beta -
P6H84_RS11640 (2409866) 2409866..2410519 + 654 WP_000045650.1 formate dehydrogenase-N subunit gamma -
P6H84_RS11645 (2410570) 2410570..2410854 - 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
P6H84_RS11650 (2410854) 2410854..2411132 - 279 WP_000605676.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P6H84_RS11655 (2411318) 2411318..2412328 - 1011 WP_000642407.1 alcohol dehydrogenase AdhP -
P6H84_RS11660 (2412462) 2412462..2414159 - 1698 WP_000433464.1 malate dehydrogenase -
P6H84_RS11665 (2414316) 2414316..2414453 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
P6H84_RS11670 (2414555) 2414555..2414770 - 216 WP_000495766.1 biofilm-dependent modulation protein -
P6H84_RS11675 (2415115) 2415115..2415546 + 432 WP_000152305.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10521.10 Da        Isoelectric Point: 7.3562

>T275932 WP_000605676.1 NZ_CP121153:c2411132-2410854 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT275932 WP_000781370.1 NZ_CP121153:c2410854-2410570 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G6T1

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References