Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 764875..765568 Replicon chromosome
Accession NZ_CP121153
Organism Escherichia coli strain E57

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag P6H84_RS03685 Protein ID WP_000415584.1
Coordinates 764875..765171 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag P6H84_RS03690 Protein ID WP_000650107.1
Coordinates 765173..765568 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H84_RS03650 (759963) 759963..760277 - 315 WP_000958598.1 putative quinol monooxygenase -
P6H84_RS03655 (760308) 760308..760889 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
P6H84_RS03660 (761208) 761208..761540 + 333 WP_023149630.1 DUF2645 family protein -
P6H84_RS03665 (761586) 761586..762935 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
P6H84_RS03670 (762932) 762932..763591 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
P6H84_RS03675 (763743) 763743..764135 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
P6H84_RS03680 (764188) 764188..764670 + 483 WP_000183505.1 GyrI-like domain-containing protein -
P6H84_RS03685 (764875) 764875..765171 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
P6H84_RS03690 (765173) 765173..765568 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
P6H84_RS03695 (765701) 765701..767308 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
P6H84_RS03700 (767446) 767446..769704 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T275927 WP_000415584.1 NZ_CP121153:764875-765171 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT275927 WP_000650107.1 NZ_CP121153:765173-765568 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References