Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 653624..654423 Replicon chromosome
Accession NZ_CP121153
Organism Escherichia coli strain E57

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag P6H84_RS03150 Protein ID WP_000347273.1
Coordinates 653624..654088 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID D6JF08
Locus tag P6H84_RS03155 Protein ID WP_001308975.1
Coordinates 654088..654423 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H84_RS03120 (648625) 648625..649059 - 435 WP_000948834.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
P6H84_RS03125 (649077) 649077..649955 - 879 WP_001298314.1 PTS N-acetylgalactosamine transporter subunit IID -
P6H84_RS03130 (649945) 649945..650724 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
P6H84_RS03135 (650735) 650735..651208 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
P6H84_RS03140 (651231) 651231..652511 - 1281 WP_000681961.1 tagatose-bisphosphate aldolase subunit KbaZ -
P6H84_RS03145 (652760) 652760..653569 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
P6H84_RS03150 (653624) 653624..654088 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
P6H84_RS03155 (654088) 654088..654423 - 336 WP_001308975.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
P6H84_RS03160 (654572) 654572..656143 - 1572 WP_001273756.1 galactarate dehydratase -
P6H84_RS03165 (656518) 656518..657852 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
P6H84_RS03170 (657868) 657868..658638 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T275926 WP_000347273.1 NZ_CP121153:c654088-653624 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12343.97 Da        Isoelectric Point: 4.8616

>AT275926 WP_001308975.1 NZ_CP121153:c654423-654088 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB D6JF08

References