Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 5056442..5057044 Replicon chromosome
Accession NZ_CP121151
Organism Escherichia coli strain E47

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag P6H31_RS25005 Protein ID WP_000897305.1
Coordinates 5056733..5057044 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P6H31_RS25000 Protein ID WP_000356397.1
Coordinates 5056442..5056732 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H31_RS24975 (5052367) 5052367..5053269 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
P6H31_RS24980 (5053266) 5053266..5053901 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
P6H31_RS24985 (5053898) 5053898..5054827 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
P6H31_RS24990 (5055157) 5055157..5055399 - 243 WP_001087409.1 protein YiiF -
P6H31_RS24995 (5055619) 5055619..5055837 - 219 WP_001315930.1 CopG family transcriptional regulator -
P6H31_RS25000 (5056442) 5056442..5056732 - 291 WP_000356397.1 NadS family protein Antitoxin
P6H31_RS25005 (5056733) 5056733..5057044 - 312 WP_000897305.1 hypothetical protein Toxin
P6H31_RS25010 (5057273) 5057273..5058181 + 909 WP_001162704.1 alpha/beta hydrolase -
P6H31_RS25015 (5058245) 5058245..5059186 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
P6H31_RS25020 (5059231) 5059231..5059668 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
P6H31_RS25025 (5059665) 5059665..5060537 - 873 WP_000920762.1 virulence factor BrkB family protein -
P6H31_RS25030 (5060531) 5060531..5061130 - 600 WP_001295269.1 glucose-1-phosphatase -
P6H31_RS25035 (5061229) 5061229..5062014 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T275918 WP_000897305.1 NZ_CP121151:c5057044-5056733 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT275918 WP_000356397.1 NZ_CP121151:c5056732-5056442 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References