Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4789558..4790160 Replicon chromosome
Accession NZ_CP121149
Organism Escherichia coli strain E14

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P1I99_RS23210 Protein ID WP_001593848.1
Coordinates 4789849..4790160 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P1I99_RS23205 Protein ID WP_000356397.1
Coordinates 4789558..4789848 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1I99_RS23180 (4785503) 4785503..4786405 + 903 WP_169759669.1 formate dehydrogenase O subunit beta -
P1I99_RS23185 (4786402) 4786402..4787037 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
P1I99_RS23190 (4787034) 4787034..4787963 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
P1I99_RS23195 (4788293) 4788293..4788535 - 243 WP_001087409.1 protein YiiF -
P1I99_RS23200 (4788754) 4788754..4788972 - 219 WP_001295676.1 CopG family transcriptional regulator -
P1I99_RS23205 (4789558) 4789558..4789848 - 291 WP_000356397.1 NadS family protein Antitoxin
P1I99_RS23210 (4789849) 4789849..4790160 - 312 WP_001593848.1 hypothetical protein Toxin
P1I99_RS23215 (4790389) 4790389..4791282 + 894 WP_276169778.1 alpha/beta hydrolase -
P1I99_RS23220 (4791361) 4791361..4792302 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
P1I99_RS23225 (4792347) 4792347..4792784 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
P1I99_RS23230 (4792781) 4792781..4793653 - 873 WP_000920762.1 virulence factor BrkB family protein -
P1I99_RS23235 (4793647) 4793647..4794246 - 600 WP_001295269.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12174.15 Da        Isoelectric Point: 9.7791

>T275895 WP_001593848.1 NZ_CP121149:c4790160-4789849 [Escherichia coli]
MLFIETEIFTEDVQKPLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT275895 WP_000356397.1 NZ_CP121149:c4789848-4789558 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References