Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3895530..3896071 Replicon chromosome
Accession NZ_CP121149
Organism Escherichia coli strain E14

Toxin (Protein)


Gene name yafQ Uniprot ID E9TC49
Locus tag P1I99_RS19015 Protein ID WP_000615982.1
Coordinates 3895793..3896071 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag P1I99_RS19010 Protein ID WP_000729704.1
Coordinates 3895530..3895790 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1I99_RS18985 (3890566) 3890566..3891705 + 1140 WP_000785662.1 flagellar type III secretion system protein FlhB -
P1I99_RS18990 (3891689) 3891689..3893782 + 2094 WP_001140806.1 flagellar biosynthesis protein FlhA -
P1I99_RS18995 (3893887) 3893887..3894165 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
P1I99_RS19000 (3894158) 3894158..3894514 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
P1I99_RS19005 (3894571) 3894571..3895344 - 774 WP_000543899.1 C40 family peptidase -
P1I99_RS19010 (3895530) 3895530..3895790 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
P1I99_RS19015 (3895793) 3895793..3896071 + 279 WP_000615982.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
P1I99_RS19020 (3896227) 3896227..3896967 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
P1I99_RS19025 (3896938) 3896938..3897705 - 768 WP_000333380.1 class II glutamine amidotransferase -
P1I99_RS19030 (3897911) 3897911..3898489 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10816.59 Da        Isoelectric Point: 10.0702

>T275892 WP_000615982.1 NZ_CP121149:3895793-3896071 [Escherichia coli]
MIQRDIEYSGQFSKDVKVAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT275892 WP_000729704.1 NZ_CP121149:3895530-3895790 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References