Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 865444..866090 Replicon chromosome
Accession NZ_CP121141
Organism Klebsiella pneumoniae strain UHD-58_PH

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P8T47_RS04410 Protein ID WP_032415766.1
Coordinates 865743..866090 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag P8T47_RS04405 Protein ID WP_002920557.1
Coordinates 865444..865743 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T47_RS04385 (P8T47_04385) 861650..862408 - 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -
P8T47_RS04390 (P8T47_04390) 862458..863288 - 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
P8T47_RS04395 (P8T47_04395) 863339..863668 - 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
P8T47_RS04400 (P8T47_04400) 863873..865381 + 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
P8T47_RS04405 (P8T47_04405) 865444..865743 - 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
P8T47_RS04410 (P8T47_04410) 865743..866090 - 348 WP_032415766.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P8T47_RS04415 (P8T47_04415) 866266..868713 - 2448 WP_002920561.1 glycogen phosphorylase -
P8T47_RS04420 (P8T47_04420) 868731..870164 - 1434 WP_002920564.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13535.49 Da        Isoelectric Point: 5.2054

>T275808 WP_032415766.1 NZ_CP121141:c866090-865743 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNENRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT275808 WP_002920557.1 NZ_CP121141:c865743-865444 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References