Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4672026..4672672 Replicon chromosome
Accession NZ_CP121139
Organism Klebsiella pneumoniae strain UHD-4_PH

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P8T35_RS22745 Protein ID WP_032415766.1
Coordinates 4672325..4672672 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag P8T35_RS22740 Protein ID WP_002920557.1
Coordinates 4672026..4672325 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T35_RS22720 (P8T35_22720) 4668232..4668990 - 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -
P8T35_RS22725 (P8T35_22725) 4669040..4669870 - 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
P8T35_RS22730 (P8T35_22730) 4669921..4670250 - 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
P8T35_RS22735 (P8T35_22735) 4670455..4671963 + 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
P8T35_RS22740 (P8T35_22740) 4672026..4672325 - 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
P8T35_RS22745 (P8T35_22745) 4672325..4672672 - 348 WP_032415766.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P8T35_RS22750 (P8T35_22750) 4672848..4675295 - 2448 WP_002920561.1 glycogen phosphorylase -
P8T35_RS22755 (P8T35_22755) 4675313..4676746 - 1434 WP_002920564.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13535.49 Da        Isoelectric Point: 5.2054

>T275802 WP_032415766.1 NZ_CP121139:c4672672-4672325 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNENRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT275802 WP_002920557.1 NZ_CP121139:c4672325-4672026 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References