Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4455865..4456511 Replicon chromosome
Accession NZ_CP121137
Organism Klebsiella pneumoniae strain UHD-33_PH

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P8T49_RS21395 Protein ID WP_032415766.1
Coordinates 4455865..4456212 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag P8T49_RS21400 Protein ID WP_002920557.1
Coordinates 4456212..4456511 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T49_RS21385 (P8T49_21385) 4451791..4453224 + 1434 WP_002920564.1 glycogen synthase GlgA -
P8T49_RS21390 (P8T49_21390) 4453242..4455689 + 2448 WP_002920561.1 glycogen phosphorylase -
P8T49_RS21395 (P8T49_21395) 4455865..4456212 + 348 WP_032415766.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P8T49_RS21400 (P8T49_21400) 4456212..4456511 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
P8T49_RS21405 (P8T49_21405) 4456574..4458082 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
P8T49_RS21410 (P8T49_21410) 4458287..4458616 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
P8T49_RS21415 (P8T49_21415) 4458667..4459497 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
P8T49_RS21420 (P8T49_21420) 4459547..4460305 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13535.49 Da        Isoelectric Point: 5.2054

>T275789 WP_032415766.1 NZ_CP121137:4455865-4456212 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNENRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT275789 WP_002920557.1 NZ_CP121137:4456212-4456511 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References