Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3897022..3897668 Replicon chromosome
Accession NZ_CP121131
Organism Klebsiella pneumoniae strain UHD-50_PH

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P8T45_RS18790 Protein ID WP_032415766.1
Coordinates 3897022..3897369 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag P8T45_RS18795 Protein ID WP_002920557.1
Coordinates 3897369..3897668 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T45_RS18780 (P8T45_18785) 3892948..3894381 + 1434 WP_002920564.1 glycogen synthase GlgA -
P8T45_RS18785 (P8T45_18790) 3894399..3896846 + 2448 WP_002920561.1 glycogen phosphorylase -
P8T45_RS18790 (P8T45_18795) 3897022..3897369 + 348 WP_032415766.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P8T45_RS18795 (P8T45_18800) 3897369..3897668 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
P8T45_RS18800 (P8T45_18805) 3897731..3899239 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
P8T45_RS18805 (P8T45_18810) 3899444..3899773 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
P8T45_RS18810 (P8T45_18815) 3899824..3900654 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
P8T45_RS18815 (P8T45_18820) 3900704..3901462 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13535.49 Da        Isoelectric Point: 5.2054

>T275744 WP_032415766.1 NZ_CP121131:3897022-3897369 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNENRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT275744 WP_002920557.1 NZ_CP121131:3897369-3897668 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References