Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3933691..3934375 Replicon chromosome
Accession NZ_CP121108
Organism Pantoea sp. X85

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P6287_RS18340 Protein ID WP_277974209.1
Coordinates 3934043..3934375 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P6287_RS18335 Protein ID WP_101762746.1
Coordinates 3933691..3934023 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6287_RS18320 (P6287_18320) 3930493..3932172 - 1680 WP_277974208.1 potassium-transporting ATPase subunit KdpA -
P6287_RS18325 (P6287_18325) 3932172..3932261 - 90 WP_081113208.1 K(+)-transporting ATPase subunit F -
P6287_RS18330 (P6287_18330) 3932371..3933534 - 1164 WP_192236933.1 HD-GYP domain-containing protein -
P6287_RS18335 (P6287_18335) 3933691..3934023 - 333 WP_101762746.1 HigA family addiction module antitoxin Antitoxin
P6287_RS18340 (P6287_18340) 3934043..3934375 - 333 WP_277974209.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P6287_RS18345 (P6287_18345) 3934499..3935890 - 1392 WP_277974210.1 MFS transporter -
P6287_RS18350 (P6287_18350) 3936303..3937217 + 915 WP_277974211.1 sugar ABC transporter substrate-binding protein -
P6287_RS18355 (P6287_18355) 3937298..3937792 - 495 WP_277974212.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-70)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13063.00 Da        Isoelectric Point: 9.9849

>T275693 WP_277974209.1 NZ_CP121108:c3934375-3934043 [Pantoea sp. X85]
MKGSIHSFRDDWLRLFFVYATPHKHIPAMIESALARKLDIIHAATSHHDLRSPPGNRFEALRPPLLGYYSIRINEQYRLI
FQWVNGTARDYYLDPHTYRKHRYQPLVANC

Download         Length: 333 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12618.41 Da        Isoelectric Point: 5.7065

>AT275693 WP_101762746.1 NZ_CP121108:c3934023-3933691 [Pantoea sp. X85]
MKQAMRKPTSVGDVLQYEFLEPLNLKVNDLAEMLNVHRNTVSALVNNNRKLTTEMAYRLAAVFDTSVDFWLNLQRHLDLW
EVENDARTQEELSRVTPLSAFLAQRSAVVA

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References