Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 936294..937018 Replicon chromosome
Accession NZ_CP121108
Organism Pantoea sp. X85

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P6287_RS04235 Protein ID WP_101762563.1
Coordinates 936707..937018 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P6287_RS04230 Protein ID WP_137386846.1
Coordinates 936294..936710 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6287_RS04210 (P6287_04210) 931815..933080 + 1266 WP_277974560.1 allantoate amidohydrolase -
P6287_RS04215 (P6287_04215) 933083..933577 + 495 WP_192415414.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
P6287_RS04220 (P6287_04220) 933574..933909 + 336 WP_101762537.1 hydroxyisourate hydrolase -
P6287_RS04225 (P6287_04225) 934052..936250 + 2199 WP_110867814.1 catalase/peroxidase HPI -
P6287_RS04230 (P6287_04230) 936294..936710 - 417 WP_137386846.1 transcriptional regulator Antitoxin
P6287_RS04235 (P6287_04235) 936707..937018 - 312 WP_101762563.1 type II toxin-antitoxin system HigB family toxin Toxin
P6287_RS04240 (P6287_04240) 937151..937921 - 771 WP_271460150.1 amidohydrolase -
P6287_RS04245 (P6287_04245) 937909..939069 - 1161 WP_101762533.1 pyridoxal phosphate-dependent aminotransferase -
P6287_RS04250 (P6287_04250) 939201..939815 + 615 WP_101762532.1 methylthioribulose 1-phosphate dehydratase -
P6287_RS04255 (P6287_04255) 939812..940495 + 684 WP_277974561.1 acireductone synthase -
P6287_RS04260 (P6287_04260) 940497..941039 + 543 WP_101762530.1 acireductone dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12169.89 Da        Isoelectric Point: 10.0567

>T275689 WP_101762563.1 NZ_CP121108:c937018-936707 [Pantoea sp. X85]
MHVISRKVFTEATRSFPNDAAALDATYRTLNGNDFADPDALRAFFPSLDRMKYRAKWWVINVGGNNLRVMFFADFIAQRI
FIKHVVTHAEYDKWVKHYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15391.53 Da        Isoelectric Point: 5.6263

>AT275689 WP_137386846.1 NZ_CP121108:c936710-936294 [Pantoea sp. X85]
MIAEAIQASNNLIKAVPLLGGSNAKADYEQALELVEYLIEHQPDHPLIEMLTDKVAKYEDSAPEFAAFNARVTALPGGVA
LLRVLMDQHNLNQSSFVNEIGQRSYVNRILKGERSLTDKHKAALAKRFNLPFEAFRED

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References