Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3889820..3890513 Replicon chromosome
Accession NZ_CP121087
Organism Escherichia coli strain ST3

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag P5670_RS19000 Protein ID WP_000415584.1
Coordinates 3889820..3890116 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag P5670_RS19005 Protein ID WP_000650107.1
Coordinates 3890118..3890513 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5670_RS18965 (3884899) 3884899..3885213 - 315 WP_000958598.1 putative quinol monooxygenase -
P5670_RS18970 (3885244) 3885244..3885825 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
P5670_RS18975 (3886153) 3886153..3886485 + 333 WP_000917684.1 DUF2645 family protein -
P5670_RS18980 (3886531) 3886531..3887880 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
P5670_RS18985 (3887877) 3887877..3888536 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
P5670_RS18990 (3888688) 3888688..3889080 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
P5670_RS18995 (3889133) 3889133..3889615 + 483 WP_000183505.1 GyrI-like domain-containing protein -
P5670_RS19000 (3889820) 3889820..3890116 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
P5670_RS19005 (3890118) 3890118..3890513 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
P5670_RS19010 (3890646) 3890646..3892253 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
P5670_RS19015 (3892391) 3892391..3894649 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T275676 WP_000415584.1 NZ_CP121087:3889820-3890116 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT275676 WP_000650107.1 NZ_CP121087:3890118-3890513 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References