275674

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3784067..3784866 Replicon chromosome
Accession NZ_CP121087
Organism Escherichia coli strain ST3

Toxin (Protein)


Gene name yhaV Uniprot ID B7NDB6
Locus tag P5670_RS18475 Protein ID WP_000347269.1
Coordinates 3784067..3784531 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID V0YUB5
Locus tag P5670_RS18480 Protein ID WP_001309780.1
Coordinates 3784531..3784866 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5670_RS18445 (3779068) 3779068..3779502 - 435 WP_000948818.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
P5670_RS18450 (3779520) 3779520..3780398 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
P5670_RS18455 (3780388) 3780388..3781167 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
P5670_RS18460 (3781178) 3781178..3781651 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
P5670_RS18465 (3781674) 3781674..3782954 - 1281 WP_000681943.1 tagatose-bisphosphate aldolase subunit KbaZ -
P5670_RS18470 (3783203) 3783203..3784012 + 810 WP_000072171.1 aga operon transcriptional regulator AgaR -
P5670_RS18475 (3784067) 3784067..3784531 - 465 WP_000347269.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
P5670_RS18480 (3784531) 3784531..3784866 - 336 WP_001309780.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
P5670_RS18485 (3785015) 3785015..3786586 - 1572 WP_001273738.1 galactarate dehydratase -
P5670_RS18490 (3786961) 3786961..3788295 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
P5670_RS18495 (3788311) 3788311..3789081 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3784067..3795235 11168


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17806.22 Da        Isoelectric Point: 9.6924

>T275674 WP_000347269.1 NZ_CP121087:c3784531-3784067 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTREAEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12345.94 Da        Isoelectric Point: 4.8616

>AT275674 WP_001309780.1 NZ_CP121087:c3784866-3784531 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNT
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IY86

Antitoxin

Source ID Structure
AlphaFold DB V0YUB5

References