Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 2418774..2419186 Replicon chromosome
Accession NZ_CP121087
Organism Escherichia coli strain ST3

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag P5670_RS11955 Protein ID WP_000132601.1
Coordinates 2418845..2419186 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 2418774..2418850 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5670_RS11945 (2415637) 2415637..2417226 + 1590 WP_001063204.1 type I restriction-modification system methyltransferase -
P5670_RS11950 (2417223) 2417223..2418617 + 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
- (2418774) 2418774..2418850 - 77 NuclAT_12 - Antitoxin
- (2418774) 2418774..2418850 - 77 NuclAT_12 - Antitoxin
- (2418774) 2418774..2418850 - 77 NuclAT_12 - Antitoxin
- (2418774) 2418774..2418850 - 77 NuclAT_12 - Antitoxin
- (2418774) 2418774..2418850 - 77 NuclAT_13 - Antitoxin
- (2418774) 2418774..2418850 - 77 NuclAT_13 - Antitoxin
- (2418774) 2418774..2418850 - 77 NuclAT_13 - Antitoxin
- (2418774) 2418774..2418850 - 77 NuclAT_13 - Antitoxin
P5670_RS11955 (2418845) 2418845..2419186 + 342 WP_000132601.1 endoribonuclease SymE Toxin
P5670_RS11960 (2419348) 2419348..2420727 + 1380 WP_032148299.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
P5670_RS11965 (2420727) 2420727..2421773 + 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2417223..2432140 14917


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T275665 WP_000132601.1 NZ_CP121087:2418845-2419186 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT275665 NZ_CP121087:c2418850-2418774 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References