Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2332622..2332880 Replicon chromosome
Accession NZ_CP121087
Organism Escherichia coli strain ST3

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag P5670_RS11535 Protein ID WP_000809168.1
Coordinates 2332728..2332880 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 2332622..2332679 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5670_RS11520 2329014..2329973 + 960 WP_000871674.1 hypothetical protein -
P5670_RS11525 2330011..2330910 - 900 WP_001300855.1 transcriptional activator NhaR -
P5670_RS11530 2330976..2332142 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 2332622..2332679 - 58 - - Antitoxin
P5670_RS11535 2332728..2332880 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
P5670_RS11540 2332984..2334114 - 1131 WP_001118464.1 molecular chaperone DnaJ -
P5670_RS11545 2334203..2336119 - 1917 WP_000516135.1 molecular chaperone DnaK -
P5670_RS11550 2336495..2336899 + 405 WP_000843584.1 DUF2541 family protein -
P5670_RS11555 2336925..2337638 + 714 WP_001102367.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T275664 WP_000809168.1 NZ_CP121087:2332728-2332880 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT275664 NZ_CP121087:c2332679-2332622 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References