Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2034306..2034956 Replicon chromosome
Accession NZ_CP121087
Organism Escherichia coli strain ST3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P5670_RS10170 Protein ID WP_000263532.1
Coordinates 2034615..2034956 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID U9YXQ7
Locus tag P5670_RS10165 Protein ID WP_000212552.1
Coordinates 2034306..2034605 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5670_RS10140 (2029754) 2029754..2030065 - 312 WP_000415004.1 hypothetical protein -
P5670_RS10145 (2030070) 2030070..2030462 - 393 WP_000285322.1 flagellar export chaperone FliS -
P5670_RS10150 (2030485) 2030485..2031801 - 1317 WP_000609678.1 flagellar filament capping protein FliD -
P5670_RS10155 (2032006) 2032006..2032920 - 915 WP_000949083.1 lateral flagellin LafA -
P5670_RS10160 (2033406) 2033406..2034248 + 843 WP_000022366.1 winged helix-turn-helix domain-containing protein -
P5670_RS10165 (2034306) 2034306..2034605 - 300 WP_000212552.1 helix-turn-helix transcriptional regulator Antitoxin
P5670_RS10170 (2034615) 2034615..2034956 - 342 WP_000263532.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P5670_RS10175 (2035032) 2035032..2036009 - 978 WP_001195938.1 hypothetical protein -
P5670_RS10180 (2036026) 2036026..2036955 - 930 WP_001266799.1 flagellar hook-associated protein FlgL -
P5670_RS10185 (2036970) 2036970..2038346 - 1377 WP_000367245.1 flagellar hook-associated protein FlgK -
P5670_RS10190 (2038522) 2038522..2038821 - 300 WP_000867281.1 rod-binding protein -
P5670_RS10195 (2038821) 2038821..2039921 - 1101 WP_001181876.1 flagellar basal body P-ring protein FlgI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2024015..2034959 10944


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13031.86 Da        Isoelectric Point: 6.4677

>T275663 WP_000263532.1 NZ_CP121087:c2034956-2034615 [Escherichia coli]
MWDVETTETFDNWFDAQTVALKEDLLAAMLILAEYGPQLGRPFADTVNDSQFSNMKELRVQHQGNPVRAFFAFDPARRGI
VLCAGDKTGLNEKKFYRDMIKLADSEYRKHLKK

Download         Length: 342 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11004.86 Da        Isoelectric Point: 9.7665

>AT275663 WP_000212552.1 NZ_CP121087:c2034605-2034306 [Escherichia coli]
MATLKELMAKQSPESQVRIAAKVEEMRQTIALHQLREELNISQTEMAAAMGIKQPTLAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPNGKRIAFQI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB U9YXQ7

References