Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4659127..4659729 Replicon chromosome
Accession NZ_CP121076
Organism Salmonella enterica subsp. enterica serovar Infantis strain R22.3740

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag P8I06_RS22740 Protein ID WP_001159630.1
Coordinates 4659418..4659729 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P8I06_RS22735 Protein ID WP_000362050.1
Coordinates 4659127..4659417 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8I06_RS22720 (4656620) 4656620..4657522 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
P8I06_RS22725 (4657519) 4657519..4658154 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
P8I06_RS22730 (4658151) 4658151..4659080 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
P8I06_RS22735 (4659127) 4659127..4659417 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
P8I06_RS22740 (4659418) 4659418..4659729 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
P8I06_RS22745 (4659947) 4659947..4660876 + 930 WP_021294279.1 alpha/beta hydrolase -
P8I06_RS22750 (4660962) 4660962..4661273 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
P8I06_RS22755 (4661270) 4661270..4661716 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
P8I06_RS22760 (4661731) 4661731..4662672 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
P8I06_RS22765 (4662717) 4662717..4663154 - 438 WP_023993693.1 D-aminoacyl-tRNA deacylase -
P8I06_RS22770 (4663151) 4663151..4664023 - 873 WP_000921423.1 virulence factor BrkB family protein -
P8I06_RS22775 (4664017) 4664017..4664616 - 600 WP_000965698.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T275647 WP_001159630.1 NZ_CP121076:c4659729-4659418 [Salmonella enterica subsp. enterica serovar Infantis]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT275647 WP_000362050.1 NZ_CP121076:c4659417-4659127 [Salmonella enterica subsp. enterica serovar Infantis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References