Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4659529..4660131 Replicon chromosome
Accession NZ_CP121073
Organism Salmonella enterica subsp. enterica serovar Infantis strain R22.2169

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag P8I07_RS22745 Protein ID WP_001159630.1
Coordinates 4659820..4660131 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P8I07_RS22740 Protein ID WP_000362050.1
Coordinates 4659529..4659819 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8I07_RS22725 (4657022) 4657022..4657924 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
P8I07_RS22730 (4657921) 4657921..4658556 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
P8I07_RS22735 (4658553) 4658553..4659482 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
P8I07_RS22740 (4659529) 4659529..4659819 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
P8I07_RS22745 (4659820) 4659820..4660131 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
P8I07_RS22750 (4660349) 4660349..4661278 + 930 WP_021294279.1 alpha/beta hydrolase -
P8I07_RS22755 (4661364) 4661364..4661675 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
P8I07_RS22760 (4661672) 4661672..4662118 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
P8I07_RS22765 (4662133) 4662133..4663074 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
P8I07_RS22770 (4663119) 4663119..4663556 - 438 WP_023993693.1 D-aminoacyl-tRNA deacylase -
P8I07_RS22775 (4663553) 4663553..4664425 - 873 WP_000921423.1 virulence factor BrkB family protein -
P8I07_RS22780 (4664419) 4664419..4665018 - 600 WP_000965698.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T275611 WP_001159630.1 NZ_CP121073:c4660131-4659820 [Salmonella enterica subsp. enterica serovar Infantis]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT275611 WP_000362050.1 NZ_CP121073:c4659819-4659529 [Salmonella enterica subsp. enterica serovar Infantis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References