Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4659772..4660374 Replicon chromosome
Accession NZ_CP121070
Organism Salmonella enterica subsp. enterica serovar Infantis strain R22.0044

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag P8I10_RS22735 Protein ID WP_001159630.1
Coordinates 4660063..4660374 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P8I10_RS22730 Protein ID WP_000362050.1
Coordinates 4659772..4660062 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8I10_RS22715 (4657265) 4657265..4658167 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
P8I10_RS22720 (4658164) 4658164..4658799 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
P8I10_RS22725 (4658796) 4658796..4659725 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
P8I10_RS22730 (4659772) 4659772..4660062 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
P8I10_RS22735 (4660063) 4660063..4660374 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
P8I10_RS22740 (4660592) 4660592..4661521 + 930 WP_021294279.1 alpha/beta hydrolase -
P8I10_RS22745 (4661607) 4661607..4661918 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
P8I10_RS22750 (4661915) 4661915..4662361 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
P8I10_RS22755 (4662376) 4662376..4663317 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
P8I10_RS22760 (4663362) 4663362..4663799 - 438 WP_023993693.1 D-aminoacyl-tRNA deacylase -
P8I10_RS22765 (4663796) 4663796..4664668 - 873 WP_000921423.1 virulence factor BrkB family protein -
P8I10_RS22770 (4664662) 4664662..4665261 - 600 WP_000965698.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T275590 WP_001159630.1 NZ_CP121070:c4660374-4660063 [Salmonella enterica subsp. enterica serovar Infantis]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT275590 WP_000362050.1 NZ_CP121070:c4660062-4659772 [Salmonella enterica subsp. enterica serovar Infantis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References