Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4666000..4666602 Replicon chromosome
Accession NZ_CP121068
Organism Salmonella enterica subsp. enterica serovar Infantis strain R21.1575

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag P8I08_RS22775 Protein ID WP_001159630.1
Coordinates 4666291..4666602 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P8I08_RS22770 Protein ID WP_000362050.1
Coordinates 4666000..4666290 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8I08_RS22755 (4663493) 4663493..4664395 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
P8I08_RS22760 (4664392) 4664392..4665027 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
P8I08_RS22765 (4665024) 4665024..4665953 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
P8I08_RS22770 (4666000) 4666000..4666290 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
P8I08_RS22775 (4666291) 4666291..4666602 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
P8I08_RS22780 (4666820) 4666820..4667749 + 930 WP_021294279.1 alpha/beta hydrolase -
P8I08_RS22785 (4667835) 4667835..4668146 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
P8I08_RS22790 (4668143) 4668143..4668589 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
P8I08_RS22795 (4668604) 4668604..4669545 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
P8I08_RS22800 (4669590) 4669590..4670027 - 438 WP_023993693.1 D-aminoacyl-tRNA deacylase -
P8I08_RS22805 (4670024) 4670024..4670896 - 873 WP_000921423.1 virulence factor BrkB family protein -
P8I08_RS22810 (4670890) 4670890..4671489 - 600 WP_000965698.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T275569 WP_001159630.1 NZ_CP121068:c4666602-4666291 [Salmonella enterica subsp. enterica serovar Infantis]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT275569 WP_000362050.1 NZ_CP121068:c4666290-4666000 [Salmonella enterica subsp. enterica serovar Infantis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References