275548

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4659011..4659613 Replicon chromosome
Accession NZ_CP121066
Organism Salmonella enterica subsp. enterica serovar Infantis strain R21.0914

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag P8I09_RS22745 Protein ID WP_001159630.1
Coordinates 4659302..4659613 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P8I09_RS22740 Protein ID WP_000362050.1
Coordinates 4659011..4659301 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8I09_RS22725 (4656504) 4656504..4657406 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
P8I09_RS22730 (4657403) 4657403..4658038 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
P8I09_RS22735 (4658035) 4658035..4658964 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
P8I09_RS22740 (4659011) 4659011..4659301 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
P8I09_RS22745 (4659302) 4659302..4659613 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
P8I09_RS22750 (4659831) 4659831..4660760 + 930 WP_021294279.1 alpha/beta hydrolase -
P8I09_RS22755 (4660846) 4660846..4661157 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
P8I09_RS22760 (4661154) 4661154..4661600 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
P8I09_RS22765 (4661615) 4661615..4662556 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
P8I09_RS22770 (4662601) 4662601..4663038 - 438 WP_023993693.1 D-aminoacyl-tRNA deacylase -
P8I09_RS22775 (4663035) 4663035..4663907 - 873 WP_000921423.1 virulence factor BrkB family protein -
P8I09_RS22780 (4663901) 4663901..4664500 - 600 WP_000965698.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T275548 WP_001159630.1 NZ_CP121066:c4659613-4659302 [Salmonella enterica subsp. enterica serovar Infantis]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT275548 WP_000362050.1 NZ_CP121066:c4659301-4659011 [Salmonella enterica subsp. enterica serovar Infantis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References