Detailed information of TA system TA275518

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2443698..2443923
• Replicon: chromosome
• Accession: NZ_CP121003
• Organism: Salmonella enterica strain 31A

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: P6590_RS11885
• Protein ID: WP_000813254.1
• Coordinates: 2443698..2443853 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2443865..2443923 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P6590_RS11850	2438805..2439086	-	282	WP_000445513.1	phage holin family protein	-
P6590_RS11855	2439076..2439264	-	189	WP_001688615.1	putative holin	-
P6590_RS11860	2439258..2439581	-	324	Protein_2322	tellurite/colicin resistance protein	-
P6590_RS11865	2441752..2442288	-	537	WP_000640113.1	DUF1133 family protein	-
P6590_RS11870	2442285..2442575	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
P6590_RS11875	2442575..2443174	-	600	WP_000940751.1	DUF1367 family protein	-
P6590_RS11880	2443237..2443407	-	171	WP_000734094.1	hypothetical protein	-
P6590_RS11885	2443698..2443853	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2443865..2443923	+	59	-	-	Antitoxin
P6590_RS11890	2444280..2445212	+	933	WP_000556390.1	hypothetical protein	-
P6590_RS11895	2445209..2445763	+	555	WP_001033796.1	hypothetical protein	-
P6590_RS11900	2445925..2446254	-	330	WP_001676916.1	DUF977 family protein	-
P6590_RS11905	2446298..2446345	-	48	Protein_2331	hypothetical protein	-
P6590_RS11910	2446527..2446994	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
P6590_RS11915	2447379..2447534	+	156	WP_085981757.1	DUF1391 family protein	-
P6590_RS11920	2447642..2448163	-	522	WP_000004762.1	super-infection exclusion protein B	-
P6590_RS11925	2448601..2448822	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2438263..2450134	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T275518 WP_000813254.1 NZ_CP121003:c2443853-2443698 [Salmonella enterica]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

Antitoxin

Nucleotide

• Length: 59 bp

>AT275518 NZ_CP121003:2443865-2443923 [Salmonella enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin