275509

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 91281..91932 Replicon plasmid pXJ22MSE3-1
Accession NZ_CP120979
Organism Moellerella wisconsensis strain XJ22MSE3

Toxin (Protein)


Gene name higB Uniprot ID A0A857SB97
Locus tag P8A17_RS16235 Protein ID WP_042847389.1
Coordinates 91582..91932 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P8A17_RS16230 Protein ID WP_277850713.1
Coordinates 91281..91580 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8A17_RS16200 87590..87799 + 210 WP_042847397.1 hypothetical protein -
P8A17_RS16205 87876..88190 + 315 WP_042847396.1 hypothetical protein -
P8A17_RS16210 88464..88682 + 219 WP_042847394.1 hypothetical protein -
P8A17_RS16215 88716..89240 + 525 WP_052219403.1 hypothetical protein -
P8A17_RS16220 89672..90073 + 402 WP_042847392.1 hypothetical protein -
P8A17_RS16225 90124..91140 - 1017 WP_042847391.1 hypothetical protein -
P8A17_RS16230 91281..91580 - 300 WP_277850713.1 XRE family transcriptional regulator Antitoxin
P8A17_RS16235 91582..91932 - 351 WP_042847389.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P8A17_RS16240 92117..92695 + 579 WP_067423959.1 recombinase family protein -
P8A17_RS16245 92772..94049 + 1278 WP_109912805.1 hypothetical protein -
P8A17_RS16250 94284..94619 + 336 WP_067423974.1 PerC family transcriptional regulator -
P8A17_RS16255 94697..95086 + 390 WP_067423972.1 hypothetical protein -
P8A17_RS16260 95115..95819 + 705 WP_137022593.1 hypothetical protein -
P8A17_RS16265 95834..96364 + 531 WP_067423968.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid lnu(G) / ant(2'')-Ia / catB8 / blaOXA-10 / ant(3'')-Ia / dfrA1 / qacE / sul1 / blaNDM-1 / mph(E) / msr(E) / fosA3 / aph(3')-Ia / qnrA1 / ARR-3 / aac(6')-Ib-cr / floR / aph(4)-Ia / aac(3)-IVa - 1..325408 325408
- flank IS/Tn - - 92117..92695 578


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-84)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13437.50 Da        Isoelectric Point: 5.2661

>T275509 WP_042847389.1 NZ_CP120979:c91932-91582 [Moellerella wisconsensis]
MWEILTRDLFDSWFEEQNEETQIEVLAVLMILREDGPNLGRPQVDTLKGSQFPNMKELRIQVGGHPIRACFAFDPIRRGI
VLCAGDKKGKDETRFYKKLIKMADAEYAAHLLEQEK

Download         Length: 351 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11005.67 Da        Isoelectric Point: 7.0171

>AT275509 WP_277850713.1 NZ_CP120979:c91580-91281 [Moellerella wisconsensis]
MSTLNELLAKQSPETQAKIEDRAEEIRREITLAKIREELKLSQTELAQSLGVSQPSIAKLENVDNDPKLSTLKRYIKALG
GELSIDVTLPNGKRIGLHL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A857SB97

Antitoxin

Source ID Structure

References