Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1946356..1946869 Replicon chromosome
Accession NZ_CP120953
Organism Streptococcus agalactiae strain GBSIR0001

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag P6F23_RS09875 Protein ID WP_000481712.1
Coordinates 1946356..1946610 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag P6F23_RS09880 Protein ID WP_000387490.1
Coordinates 1946603..1946869 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6F23_RS09855 (P6F23_09855) 1942127..1944628 - 2502 WP_000239404.1 ATP-binding protein -
P6F23_RS09860 (P6F23_09860) 1944649..1945059 - 411 WP_000390749.1 conjugal transfer protein -
P6F23_RS09865 (P6F23_09865) 1945063..1945329 - 267 WP_001055037.1 hypothetical protein -
P6F23_RS09870 (P6F23_09870) 1945350..1946303 - 954 WP_000565541.1 conjugal transfer protein -
P6F23_RS09875 (P6F23_09875) 1946356..1946610 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
P6F23_RS09880 (P6F23_09880) 1946603..1946869 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
P6F23_RS09885 (P6F23_09885) 1947014..1947487 - 474 WP_000560386.1 hypothetical protein -
P6F23_RS09890 (P6F23_09890) 1947495..1947977 - 483 WP_000383283.1 antirestriction protein ArdA -
P6F23_RS09895 (P6F23_09895) 1948030..1948302 - 273 WP_000072643.1 hypothetical protein -
P6F23_RS09900 (P6F23_09900) 1948434..1948787 - 354 WP_000571928.1 helix-turn-helix transcriptional regulator -
P6F23_RS09905 (P6F23_09905) 1948780..1949010 - 231 WP_001866982.1 helix-turn-helix transcriptional regulator -
P6F23_RS09910 (P6F23_09910) 1948997..1949374 - 378 WP_000287185.1 hypothetical protein -
P6F23_RS09915 (P6F23_09915) 1949390..1950622 - 1233 WP_000338839.1 replication initiation factor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - cfa/cfb 1931189..1970791 39602


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T275476 WP_000481712.1 NZ_CP120953:c1946610-1946356 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT275476 WP_000387490.1 NZ_CP120953:c1946869-1946603 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References