Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1599268..1599968 Replicon chromosome
Accession NZ_CP120948
Organism Burkholderia contaminans strain 5080

Toxin (Protein)


Gene name mqsR Uniprot ID A0A1E3FT75
Locus tag P4E65_RS24695 Protein ID WP_039357707.1
Coordinates 1599672..1599968 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A4R4BTY4
Locus tag P4E65_RS24690 Protein ID WP_039357704.1
Coordinates 1599268..1599669 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4E65_RS24670 (P4E65_24670) 1594923..1596275 - 1353 WP_039357693.1 LLM class flavin-dependent oxidoreductase -
P4E65_RS24675 (P4E65_24675) 1596283..1597332 - 1050 WP_039357696.1 LLM class flavin-dependent oxidoreductase -
P4E65_RS24680 (P4E65_24680) 1597385..1598332 - 948 WP_039357698.1 ABC transporter substrate-binding protein -
P4E65_RS24685 (P4E65_24685) 1598389..1598949 - 561 WP_039357701.1 GNAT family N-acetyltransferase -
P4E65_RS24690 (P4E65_24690) 1599268..1599669 - 402 WP_039357704.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
P4E65_RS24695 (P4E65_24695) 1599672..1599968 - 297 WP_039357707.1 type II toxin-antitoxin system MqsR family toxin Toxin
P4E65_RS24700 (P4E65_24700) 1600072..1601115 - 1044 WP_039357711.1 succinylglutamate desuccinylase/aspartoacylase family protein -
P4E65_RS24705 (P4E65_24705) 1601367..1601651 - 285 WP_039357714.1 hypothetical protein -
P4E65_RS24710 (P4E65_24710) 1601893..1603443 - 1551 WP_039357717.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(72-109)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11206.04 Da        Isoelectric Point: 8.0535

>T275472 WP_039357707.1 NZ_CP120948:c1599968-1599672 [Burkholderia contaminans]
MEKRTPHCKLPRVKALVETGQVRLTASAVLGARLLGFTEREALDVVLSLTDLDFHKSMTTYADHTIWQDVYRPFTVRGDV
YLKLTVIDDVLIVSFKER

Download         Length: 297 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14649.94 Da        Isoelectric Point: 8.8304

>AT275472 WP_039357704.1 NZ_CP120948:c1599669-1599268 [Burkholderia contaminans]
MKCPACGAARLVRDTRDIPYTYKGRSTVVRDITGDFCPACGESVLDLDEATRLGEAITEFNKQVNATIVDPKYIAKVRKK
LKLDQREAAELFGGGVNAFSRYETGKTNPPLALVKLLKLLDRHPDLLAEVRAA

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3FT75

Antitoxin

Source ID Structure
AlphaFold DB A0A4R4BTY4

References