Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 4725539..4725951 Replicon chromosome
Accession NZ_CP120944
Organism Escherichia coli O157:H7 str. EDL933

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag P7249_RS23805 Protein ID WP_000132630.1
Coordinates 4725610..4725951 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 4725539..4725615 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7249_RS23795 (4722166) 4722166..4723635 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
P7249_RS23800 (4723635) 4723635..4725389 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- (4725539) 4725539..4725615 - 77 NuclAT_15 - Antitoxin
- (4725539) 4725539..4725615 - 77 NuclAT_15 - Antitoxin
- (4725539) 4725539..4725615 - 77 NuclAT_15 - Antitoxin
- (4725539) 4725539..4725615 - 77 NuclAT_15 - Antitoxin
- (4725539) 4725539..4725615 - 77 NuclAT_16 - Antitoxin
- (4725539) 4725539..4725615 - 77 NuclAT_16 - Antitoxin
- (4725539) 4725539..4725615 - 77 NuclAT_16 - Antitoxin
- (4725539) 4725539..4725615 - 77 NuclAT_16 - Antitoxin
P7249_RS23805 (4725610) 4725610..4725951 + 342 WP_000132630.1 endoribonuclease SymE Toxin
P7249_RS23810 (4725998) 4725998..4727161 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
P7249_RS23815 (4727209) 4727209..4728090 - 882 WP_001304007.1 DUF262 domain-containing protein -
P7249_RS23820 (4728233) 4728233..4728385 - 153 WP_001418365.1 hypothetical protein -
P7249_RS23825 (4728528) 4728528..4729940 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4717738..4738965 21227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T275461 WP_000132630.1 NZ_CP120944:4725610-4725951 [Escherichia coli O157:H7 str. EDL933]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT275461 NZ_CP120944:c4725615-4725539 [Escherichia coli O157:H7 str. EDL933]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References