275451

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2413745..2414216 Replicon chromosome
Accession NZ_CP120944
Organism Escherichia coli O157:H7 str. EDL933

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag P7249_RS12055 Protein ID WP_001303511.1
Coordinates 2413745..2414023 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag P7249_RS12060 Protein ID WP_001302048.1
Coordinates 2414025..2414216 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7249_RS12025 (2408970) 2408970..2409221 - 252 WP_000005552.1 excisionase family protein -
P7249_RS12030 (2409294) 2409294..2411765 - 2472 WP_000048458.1 exonuclease -
P7249_RS12035 (2411858) 2411858..2412049 - 192 WP_001090200.1 DUF1482 family protein -
P7249_RS12040 (2412046) 2412046..2412234 - 189 WP_000449192.1 cell division inhibition protein DicB -
P7249_RS12045 (2412803) 2412803..2413021 - 219 WP_001171930.1 protein YdfC -
P7249_RS12050 (2413093) 2413093..2413392 - 300 WP_001240334.1 hypothetical protein -
P7249_RS12055 (2413745) 2413745..2414023 - 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7249_RS12060 (2414025) 2414025..2414216 - 192 WP_001302048.1 hypothetical protein Antitoxin
P7249_RS12065 (2414237) 2414237..2414608 - 372 WP_001169686.1 hypothetical protein -
P7249_RS12070 (2414706) 2414706..2415008 + 303 WP_000172738.1 transcriptional regulator -
P7249_RS12075 (2415005) 2415005..2415430 + 426 WP_000693943.1 toxin YdaT family protein -
P7249_RS12080 (2415453) 2415453..2416415 + 963 WP_000095669.1 helix-turn-helix domain-containing protein -
P7249_RS12085 (2416422) 2416422..2417162 + 741 WP_000788938.1 ATP-binding protein -
P7249_RS12090 (2417188) 2417188..2417957 + 770 Protein_2366 DUF1627 domain-containing protein -
P7249_RS12095 (2417973) 2417973..2418368 + 396 WP_001118159.1 DUF977 family protein -
P7249_RS12100 (2418425) 2418425..2419009 + 585 WP_000206793.1 DUF551 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - nleA/espI 2398865..2455446 56581


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T275451 WP_001303511.1 NZ_CP120944:c2414023-2413745 [Escherichia coli O157:H7 str. EDL933]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT275451 WP_001302048.1 NZ_CP120944:c2414216-2414025 [Escherichia coli O157:H7 str. EDL933]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References