Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 15474..15732 Replicon chromosome
Accession NC_017652
Organism Escherichia coli str. clone D i14

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag I14_RS00085 Protein ID WP_000809168.1
Coordinates 15474..15626 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 15675..15732 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I14_RS00065 10719..11432 - 714 WP_001102391.1 acidic protein MsyB -
I14_RS00070 11458..11862 - 405 WP_000843687.1 DUF2541 family protein -
I14_RS00075 12234..14150 + 1917 WP_000516135.1 molecular chaperone DnaK -
I14_RS00080 14239..15369 + 1131 WP_001118464.1 molecular chaperone DnaJ -
I14_RS00085 15474..15626 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 15675..15732 + 58 - - Antitoxin
I14_RS00090 16241..17002 + 762 WP_001274832.1 hypothetical protein -
I14_RS00095 17022..18515 + 1494 WP_001443162.1 sulfatase-like hydrolase/transferase -
I14_RS00100 18644..19903 + 1260 WP_000494928.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T27534 WP_000809168.1 NC_017652:c15626-15474 [Escherichia coli str. 'clone D i14']
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T27534 NC_017652:c15626-15474 [Escherichia coli str. 'clone D i14']
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT27534 NC_017652:15675-15732 [Escherichia coli str. 'clone D i14']
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References