Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 624902..625479 Replicon chromosome
Accession NZ_CP120638
Organism Rhizobium sp. 32-5/1

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag P6U16_RS03250 Protein ID WP_277702591.1
Coordinates 625201..625479 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P6U16_RS03245 Protein ID WP_277702590.1
Coordinates 624902..625204 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6U16_RS03220 (P6U16_03220) 620309..621574 + 1266 WP_277702585.1 cytochrome P450 -
P6U16_RS03225 (P6U16_03225) 621583..621927 - 345 WP_277702586.1 cupin domain-containing protein -
P6U16_RS03230 (P6U16_03230) 621980..623260 - 1281 WP_277702587.1 O-acetylhomoserine aminocarboxypropyltransferase -
P6U16_RS03235 (P6U16_03235) 623398..623826 - 429 WP_277702588.1 CoA-binding protein -
P6U16_RS03240 (P6U16_03240) 624052..624888 + 837 WP_277702589.1 EamA family transporter -
P6U16_RS03245 (P6U16_03245) 624902..625204 - 303 WP_277702590.1 HigA family addiction module antitoxin Antitoxin
P6U16_RS03250 (P6U16_03250) 625201..625479 - 279 WP_277702591.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P6U16_RS03255 (P6U16_03255) 625532..626356 - 825 WP_277702592.1 enoyl-CoA hydratase -
P6U16_RS03260 (P6U16_03260) 626509..626940 + 432 WP_277702593.1 PaaI family thioesterase -
P6U16_RS03265 (P6U16_03265) 627167..627631 + 465 WP_071831290.1 50S ribosomal protein L13 -
P6U16_RS03270 (P6U16_03270) 627634..628107 + 474 WP_277702594.1 30S ribosomal protein S9 -
P6U16_RS03275 (P6U16_03275) 628216..628476 - 261 WP_277702595.1 hypothetical protein -
P6U16_RS03280 (P6U16_03280) 628497..629351 - 855 WP_277702596.1 acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10621.29 Da        Isoelectric Point: 9.8335

>T275315 WP_277702591.1 NZ_CP120638:c625479-625201 [Rhizobium sp. 32-5/1]
MIRSIANRATRQFLENGKTKFSGMDVDKAKMRAMMLHNARSLDDLVPLKSVGIHKLSGDRKMQWAMTINGPWRLCFRFED
GHAYDVEIVDDH

Download         Length: 279 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10926.47 Da        Isoelectric Point: 7.2041

>AT275315 WP_277702590.1 NZ_CP120638:c625204-624902 [Rhizobium sp. 32-5/1]
MKEHTMFEIHPGTMLKEELEARGMSGNALALALRINSGRVSEILNGKRAVSADTALRLGRFFGNDPQFWLGLQASYDLAV
ASRQNGERINLEVLPAQSAA

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References