Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3480126..3480728 Replicon chromosome
Accession NZ_CP120633
Organism Escherichia coli strain USVAST219

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag P6O79_RS17290 Protein ID WP_000897302.1
Coordinates 3480126..3480437 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P6O79_RS17295 Protein ID WP_000356397.1
Coordinates 3480438..3480728 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6O79_RS17265 (3476040) 3476040..3476639 + 600 WP_001296610.1 glucose-1-phosphatase -
P6O79_RS17270 (3476633) 3476633..3477505 + 873 WP_000920762.1 virulence factor BrkB family protein -
P6O79_RS17275 (3477502) 3477502..3477939 + 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
P6O79_RS17280 (3477984) 3477984..3478925 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
P6O79_RS17285 (3478989) 3478989..3479897 - 909 WP_001385591.1 alpha/beta hydrolase -
P6O79_RS17290 (3480126) 3480126..3480437 + 312 WP_000897302.1 hypothetical protein Toxin
P6O79_RS17295 (3480438) 3480438..3480728 + 291 WP_000356397.1 NadS family protein Antitoxin
P6O79_RS17300 (3481087) 3481087..3481365 + 279 WP_001296612.1 hypothetical protein -
P6O79_RS17305 (3481762) 3481762..3481980 + 219 WP_001251293.1 CopG family transcriptional regulator -
P6O79_RS17310 (3482165) 3482165..3482905 - 741 WP_000608806.1 hypothetical protein -
P6O79_RS17315 (3482930) 3482930..3483778 - 849 WP_001038650.1 hypothetical protein -
P6O79_RS17320 (3484068) 3484068..3484310 + 243 WP_001068514.1 CopG family transcriptional regulator -
P6O79_RS17325 (3484492) 3484492..3485421 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T275303 WP_000897302.1 NZ_CP120633:3480126-3480437 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT275303 WP_000356397.1 NZ_CP120633:3480438-3480728 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References