Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1316031..1316533 Replicon chromosome
Accession NZ_CP120633
Organism Escherichia coli strain USVAST219

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag P6O79_RS07075 Protein ID WP_000767819.1
Coordinates 1316031..1316285 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag P6O79_RS07080 Protein ID WP_001259253.1
Coordinates 1316282..1316533 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6O79_RS07050 (1311849) 1311849..1312307 - 459 WP_001531805.1 IS200/IS605-like element IS200C family transposase -
P6O79_RS07055 (1312524) 1312524..1313882 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
P6O79_RS07060 (1313872) 1313872..1313934 - 63 WP_010723108.1 membrane protein YoeI -
P6O79_RS07065 (1314149) 1314149..1315078 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
P6O79_RS07070 (1315124) 1315124..1315948 - 825 WP_000754737.1 SDR family oxidoreductase -
P6O79_RS07075 (1316031) 1316031..1316285 - 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
P6O79_RS07080 (1316282) 1316282..1316533 - 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
P6O79_RS07085 (1316816) 1316816..1316866 + 51 WP_001364200.1 his operon leader peptide -
P6O79_RS07090 (1317012) 1317012..1317911 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
P6O79_RS07095 (1317917) 1317917..1319221 + 1305 WP_001296211.1 histidinol dehydrogenase -
P6O79_RS07100 (1319218) 1319218..1320288 + 1071 WP_000108967.1 histidinol-phosphate transaminase -
P6O79_RS07105 (1320288) 1320288..1321355 + 1068 WP_000080057.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1311849..1312307 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T275296 WP_000767819.1 NZ_CP120633:c1316285-1316031 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT275296 WP_001259253.1 NZ_CP120633:c1316533-1316282 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References