Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3870921..3871462 Replicon chromosome
Accession NZ_CP120568
Organism Escherichia coli strain 582

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag P5711_RS19135 Protein ID WP_000615983.1
Coordinates 3871184..3871462 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag P5711_RS19130 Protein ID WP_000729703.1
Coordinates 3870921..3871181 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5711_RS19110 (3866606) 3866606..3867391 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
P5711_RS19115 (3867363) 3867363..3869075 + 1713 Protein_3740 flagellar biosynthesis protein FlhA -
P5711_RS19120 (3869299) 3869299..3869796 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
P5711_RS19125 (3869972) 3869972..3870711 - 740 Protein_3742 C40 family peptidase -
P5711_RS19130 (3870921) 3870921..3871181 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
P5711_RS19135 (3871184) 3871184..3871462 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
P5711_RS19140 (3871618) 3871618..3872358 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
P5711_RS19145 (3872329) 3872329..3873096 - 768 WP_000333380.1 class II glutamine amidotransferase -
P5711_RS19150 (3873302) 3873302..3873880 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T275219 WP_000615983.1 NZ_CP120568:3871184-3871462 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT275219 WP_000729703.1 NZ_CP120568:3870921-3871181 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References