275215

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2457203..2458791 Replicon chromosome
Accession NZ_CP120568
Organism Escherichia coli strain 582

Toxin (Protein)


Gene name hipA Uniprot ID S1ELM3
Locus tag P5711_RS12055 Protein ID WP_001125439.1
Coordinates 2457469..2458791 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag P5711_RS12050 Protein ID WP_001301023.1
Coordinates 2457203..2457469 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5711_RS12030 (2452220) 2452220..2453212 - 993 WP_001222721.1 autoinducer 2 ABC transporter permease LsrD -
P5711_RS12035 (2453212) 2453212..2454240 - 1029 WP_000911184.1 autoinducer 2 ABC transporter permease LsrC -
P5711_RS12040 (2454234) 2454234..2455769 - 1536 WP_001194860.1 autoinducer 2 ABC transporter ATP-binding protein LsrA -
P5711_RS12045 (2456018) 2456018..2456971 + 954 WP_000154342.1 transcriptional regulator LsrR -
P5711_RS12050 (2457203) 2457203..2457469 + 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
P5711_RS12055 (2457469) 2457469..2458791 + 1323 WP_001125439.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
P5711_RS12060 (2459103) 2459103..2459311 + 209 Protein_2357 AraC family transcriptional regulator -
P5711_RS12065 (2459566) 2459566..2460792 + 1227 Protein_2358 fimbria/pilus outer membrane usher protein -
P5711_RS12070 (2460806) 2460806..2461720 + 915 WP_277686067.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2457203..2468907 11704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49275.82 Da        Isoelectric Point: 8.2482

>T275215 WP_001125439.1 NZ_CP120568:2457469-2458791 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT275215 WP_001301023.1 NZ_CP120568:2457203-2457469 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5K98
PDB 3TPV
PDB 3DNV
PDB 3TPD
PDB 3HZI
PDB 3FBR
PDB 4YG7
PDB 3TPE
PDB 2WIU
PDB 3DNT
PDB 3TPB
PDB 3TPT
PDB 3DNU

Antitoxin

Source ID Structure

References