Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 625757..626556 Replicon chromosome
Accession NZ_CP120568
Organism Escherichia coli strain 582

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag P5711_RS03060 Protein ID WP_000347275.1
Coordinates 625757..626221 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag P5711_RS03065 Protein ID WP_001307405.1
Coordinates 626221..626556 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5711_RS03030 (620758) 620758..621192 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
P5711_RS03035 (621210) 621210..622088 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
P5711_RS03040 (622078) 622078..622857 - 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
P5711_RS03045 (622868) 622868..623341 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
P5711_RS03050 (623364) 623364..624644 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
P5711_RS03055 (624893) 624893..625702 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
P5711_RS03060 (625757) 625757..626221 - 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
P5711_RS03065 (626221) 626221..626556 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
P5711_RS03070 (626705) 626705..628276 - 1572 WP_001273753.1 galactarate dehydratase -
P5711_RS03075 (628651) 628651..629985 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
P5711_RS03080 (630001) 630001..630771 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T275205 WP_000347275.1 NZ_CP120568:c626221-625757 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT275205 WP_001307405.1 NZ_CP120568:c626556-626221 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References