Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4537336..4537748 Replicon chromosome
Accession NZ_CP120567
Organism Escherichia coli strain A0 34/86

Toxin (Protein)


Gene name symE Uniprot ID S1NWQ7
Locus tag P5707_RS22035 Protein ID WP_000132614.1
Coordinates 4537407..4537748 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4537336..4537412 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5707_RS22025 (4534011) 4534011..4535480 + 1470 WP_001540814.1 type I restriction-modification system subunit M -
P5707_RS22030 (4535480) 4535480..4537186 + 1707 WP_001100194.1 restriction endonuclease subunit S -
- (4537336) 4537336..4537412 - 77 NuclAT_6 - Antitoxin
- (4537336) 4537336..4537412 - 77 NuclAT_6 - Antitoxin
- (4537336) 4537336..4537412 - 77 NuclAT_6 - Antitoxin
- (4537336) 4537336..4537412 - 77 NuclAT_6 - Antitoxin
- (4537336) 4537336..4537412 - 77 NuclAT_7 - Antitoxin
- (4537336) 4537336..4537412 - 77 NuclAT_7 - Antitoxin
- (4537336) 4537336..4537412 - 77 NuclAT_7 - Antitoxin
- (4537336) 4537336..4537412 - 77 NuclAT_7 - Antitoxin
P5707_RS22035 (4537407) 4537407..4537748 + 342 WP_000132614.1 endoribonuclease SymE Toxin
P5707_RS22040 (4537795) 4537795..4538958 - 1164 WP_225377659.1 DUF1524 domain-containing protein -
P5707_RS22045 (4539006) 4539006..4539888 - 883 Protein_4308 DUF262 domain-containing protein -
P5707_RS22050 (4540294) 4540294..4541214 - 921 WP_000181195.1 Rpn family recombination-promoting nuclease/putative transposase -
P5707_RS22055 (4541399) 4541399..4542679 + 1281 WP_021520478.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - cheD 4521206..4539951 18745


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12266.07 Da        Isoelectric Point: 8.4982

>T275199 WP_000132614.1 NZ_CP120567:4537407-4537748 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT275199 NZ_CP120567:c4537412-4537336 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NWQ7

Antitoxin

Download structure file

References