Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2825964..2826526 Replicon chromosome
Accession NZ_CP120567
Organism Escherichia coli strain A0 34/86

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag P5707_RS13680 Protein ID WP_000605675.1
Coordinates 2825964..2826242 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag P5707_RS13685 Protein ID WP_000781370.1
Coordinates 2826242..2826526 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5707_RS13655 (2821550) 2821550..2821981 - 432 WP_000152305.1 peroxiredoxin OsmC -
P5707_RS13660 (2822326) 2822326..2822541 + 216 WP_000495766.1 biofilm-dependent modulation protein -
P5707_RS13665 (2822643) 2822643..2822780 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
P5707_RS13670 (2822937) 2822937..2824634 + 1698 WP_000433464.1 malate dehydrogenase -
P5707_RS13675 (2824768) 2824768..2825778 + 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
P5707_RS13680 (2825964) 2825964..2826242 + 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P5707_RS13685 (2826242) 2826242..2826526 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
P5707_RS13690 (2826755) 2826755..2827408 - 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
P5707_RS13695 (2827401) 2827401..2828285 - 885 WP_001240584.1 formate dehydrogenase N subunit beta -
P5707_RS13700 (2828298) 2828298..2831345 - 3048 WP_011478186.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T275193 WP_000605675.1 NZ_CP120567:2825964-2826242 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT275193 WP_000781370.1 NZ_CP120567:2826242-2826526 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References