Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 865355..866154 Replicon chromosome
Accession NZ_CP120567
Organism Escherichia coli strain A0 34/86

Toxin (Protein)


Gene name yhaV Uniprot ID Q8FDB4
Locus tag P5707_RS04170 Protein ID WP_000347252.1
Coordinates 865355..865819 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag P5707_RS04175 Protein ID WP_001296435.1
Coordinates 865819..866154 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5707_RS04140 (860356) 860356..860790 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
P5707_RS04145 (860808) 860808..861686 - 879 WP_001298314.1 PTS N-acetylgalactosamine transporter subunit IID -
P5707_RS04150 (861676) 861676..862455 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
P5707_RS04155 (862466) 862466..862939 - 474 WP_001298322.1 PTS N-acetylgalactosamine transporter subunit IIB -
P5707_RS04160 (862962) 862962..864242 - 1281 WP_000681923.1 tagatose-bisphosphate aldolase subunit KbaZ -
P5707_RS04165 (864491) 864491..865300 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
P5707_RS04170 (865355) 865355..865819 - 465 WP_000347252.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
P5707_RS04175 (865819) 865819..866154 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
P5707_RS04180 (866303) 866303..867874 - 1572 WP_001273939.1 galactarate dehydratase -
P5707_RS04185 (868249) 868249..869583 + 1335 WP_000979025.1 galactarate/glucarate/glycerate transporter GarP -
P5707_RS04190 (869599) 869599..870369 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17750.11 Da        Isoelectric Point: 9.4947

>T275182 WP_000347252.1 NZ_CP120567:c865819-865355 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEESH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT275182 WP_001296435.1 NZ_CP120567:c866154-865819 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8FDB4

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References