Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 621211..621813 Replicon chromosome
Accession NZ_CP120567
Organism Escherichia coli strain A0 34/86

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag P5707_RS03015 Protein ID WP_000897302.1
Coordinates 621211..621522 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P5707_RS03020 Protein ID WP_000356397.1
Coordinates 621523..621813 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5707_RS02985 (616240) 616240..617025 + 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -
P5707_RS02990 (617124) 617124..617723 + 600 WP_001314324.1 glucose-1-phosphatase -
P5707_RS02995 (617717) 617717..618589 + 873 WP_000920762.1 virulence factor BrkB family protein -
P5707_RS03000 (618586) 618586..619023 + 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
P5707_RS03005 (619068) 619068..620009 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
P5707_RS03010 (620073) 620073..620981 - 909 WP_001331553.1 alpha/beta hydrolase -
P5707_RS03015 (621211) 621211..621522 + 312 WP_000897302.1 hypothetical protein Toxin
P5707_RS03020 (621523) 621523..621813 + 291 WP_000356397.1 NadS family protein Antitoxin
P5707_RS03025 (622172) 622172..622450 + 279 WP_001296612.1 hypothetical protein -
P5707_RS03030 (622846) 622846..623064 + 219 WP_001314326.1 CopG family transcriptional regulator -
P5707_RS03035 (623288) 623288..624217 - 930 WP_001553788.1 formate dehydrogenase accessory protein FdhE -
P5707_RS03040 (624214) 624214..624849 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
P5707_RS03045 (624846) 624846..625748 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T275181 WP_000897302.1 NZ_CP120567:621211-621522 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT275181 WP_000356397.1 NZ_CP120567:621523-621813 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References