Detailed information of TA system TA275180

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 185108..185330
• Replicon: chromosome
• Accession: NZ_CP120567
• Organism: Escherichia coli strain A0 34/86

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A829L523
• Locus tag: P5707_RS00870
• Protein ID: WP_000170738.1
• Coordinates: 185223..185330 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	185108..185174 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P5707_RS00850	180549..181451	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
P5707_RS00855	181462..182445	+	984	WP_001196477.1	dipeptide ABC transporter ATP-binding protein	-
P5707_RS00860	182442..183446	+	1005	WP_000103580.1	dipeptide ABC transporter ATP-binding subunit DppF	-
P5707_RS00865	183476..184747	-	1272	WP_001298005.1	aromatic amino acid transport family protein	-
-	185108..185174	-	67	-	-	Antitoxin
P5707_RS00870	185223..185330	+	108	WP_000170738.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
P5707_RS00875	185706..185813	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
P5707_RS00880	185899..187578	-	1680	WP_000191567.1	cellulose biosynthesis protein BcsG	-
P5707_RS00885	187575..187766	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
P5707_RS00890	187763..189334	-	1572	WP_001204945.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
P5707_RS00895	189607..189795	+	189	WP_001063314.1	cellulose biosynthesis protein BcsR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3864.67 Da
• Isoelectric Point: 9.0157

>T275180 WP_000170738.1 NZ_CP120567:185223-185330 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASLIVNWLNKRK

Nucleotide

• Length: 108 bp

>T275180 NZ_CP120567:185223-185330 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT275180 NZ_CP120567:c185174-185108 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A829L523

Antitoxin