Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4817895..4818497 Replicon chromosome
Accession NZ_CP120563
Organism Escherichia coli strain H22

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag P5708_RS23545 Protein ID WP_000897302.1
Coordinates 4818186..4818497 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P5708_RS23540 Protein ID WP_000356397.1
Coordinates 4817895..4818185 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5708_RS23515 (4813968) 4813968..4814870 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
P5708_RS23520 (4814867) 4814867..4815502 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
P5708_RS23525 (4815499) 4815499..4816428 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
P5708_RS23530 (4816644) 4816644..4816862 - 219 WP_001314326.1 CopG family transcriptional regulator -
P5708_RS23535 (4817258) 4817258..4817536 - 279 WP_277698160.1 hypothetical protein -
P5708_RS23540 (4817895) 4817895..4818185 - 291 WP_000356397.1 NadS family protein Antitoxin
P5708_RS23545 (4818186) 4818186..4818497 - 312 WP_000897302.1 hypothetical protein Toxin
P5708_RS23550 (4818726) 4818726..4819634 + 909 WP_001331553.1 alpha/beta hydrolase -
P5708_RS23555 (4819698) 4819698..4820639 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
P5708_RS23560 (4820684) 4820684..4821121 - 438 WP_000560978.1 D-aminoacyl-tRNA deacylase -
P5708_RS23565 (4821118) 4821118..4821990 - 873 WP_000920762.1 virulence factor BrkB family protein -
P5708_RS23570 (4821984) 4821984..4822583 - 600 WP_001314324.1 glucose-1-phosphatase -
P5708_RS23575 (4822682) 4822682..4823467 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T275172 WP_000897302.1 NZ_CP120563:c4818497-4818186 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT275172 WP_000356397.1 NZ_CP120563:c4818185-4817895 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References