Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-rdlD/SymE(toxin)
Location 4214873..4215285 Replicon chromosome
Accession NZ_CP120563
Organism Escherichia coli strain H22

Toxin (Protein)


Gene name symE Uniprot ID S1NWQ7
Locus tag P5708_RS20795 Protein ID WP_000132614.1
Coordinates 4214944..4215285 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 4214873..4214949 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5708_RS20785 (4211485) 4211485..4212954 + 1470 WP_001387312.1 type I restriction-modification system subunit M -
P5708_RS20790 (4212954) 4212954..4214723 + 1770 WP_201478626.1 restriction endonuclease subunit S -
- (4214873) 4214873..4214949 - 77 NuclAT_13 - Antitoxin
- (4214873) 4214873..4214949 - 77 NuclAT_13 - Antitoxin
- (4214873) 4214873..4214949 - 77 NuclAT_13 - Antitoxin
- (4214873) 4214873..4214949 - 77 NuclAT_13 - Antitoxin
- (4214873) 4214873..4214949 - 77 NuclAT_14 - Antitoxin
- (4214873) 4214873..4214949 - 77 NuclAT_14 - Antitoxin
- (4214873) 4214873..4214949 - 77 NuclAT_14 - Antitoxin
- (4214873) 4214873..4214949 - 77 NuclAT_14 - Antitoxin
P5708_RS20795 (4214944) 4214944..4215285 + 342 WP_000132614.1 endoribonuclease SymE Toxin
P5708_RS20800 (4215332) 4215332..4216495 - 1164 WP_224153787.1 DUF1524 domain-containing protein -
P5708_RS20805 (4216549) 4216549..4217425 - 877 Protein_4075 DUF262 domain-containing protein -
P5708_RS20810 (4217831) 4217831..4218751 - 921 WP_001513532.1 Rpn family recombination-promoting nuclease/putative transposase -
P5708_RS20815 (4218936) 4218936..4220216 + 1281 WP_001338077.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - cheD 4199261..4215285 16024


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12266.07 Da        Isoelectric Point: 8.4982

>T275167 WP_000132614.1 NZ_CP120563:4214944-4215285 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT275167 NZ_CP120563:c4214949-4214873 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NWQ7

Antitoxin

Download structure file

References