Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1921432..1921934 Replicon chromosome
Accession NZ_CP120563
Organism Escherichia coli strain H22

Toxin (Protein)


Gene name yoeB Uniprot ID D8A584
Locus tag P5708_RS09250 Protein ID WP_000767828.1
Coordinates 1921680..1921934 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag P5708_RS09245 Protein ID WP_001259255.1
Coordinates 1921432..1921683 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5708_RS09220 (1916610) 1916610..1917677 - 1068 WP_000080129.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
P5708_RS09225 (1917677) 1917677..1918747 - 1071 WP_000108949.1 histidinol-phosphate transaminase -
P5708_RS09230 (1918744) 1918744..1920048 - 1305 WP_024223692.1 histidinol dehydrogenase -
P5708_RS09235 (1920054) 1920054..1920953 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
P5708_RS09240 (1921099) 1921099..1921149 - 51 WP_001364200.1 his operon leader peptide -
P5708_RS09245 (1921432) 1921432..1921683 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
P5708_RS09250 (1921680) 1921680..1921934 + 255 WP_000767828.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
P5708_RS09255 (1922017) 1922017..1922841 + 825 WP_000754740.1 SDR family oxidoreductase -
P5708_RS09260 (1922887) 1922887..1923816 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
P5708_RS09265 (1924031) 1924031..1924093 + 63 WP_010723108.1 membrane protein YoeI -
P5708_RS09270 (1924083) 1924083..1925441 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
P5708_RS09275 (1925620) 1925620..1926678 + 1059 WP_000492324.1 thiosulfate utilization transporter TsuA/YeeE -
P5708_RS09280 (1926692) 1926692..1926919 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10169.56 Da        Isoelectric Point: 8.0353

>T275158 WP_000767828.1 NZ_CP120563:1921680-1921934 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEDHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT275158 WP_001259255.1 NZ_CP120563:1921432-1921683 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G465

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References