Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1162944..1163671 Replicon chromosome
Accession NZ_CP120563
Organism Escherichia coli strain H22

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P5708_RS05645 Protein ID WP_016233494.1
Coordinates 1162944..1163255 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P5708_RS05650 Protein ID WP_000126294.1
Coordinates 1163252..1163671 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5708_RS05620 (1158880) 1158880..1160589 + 1710 WP_001288134.1 formate hydrogenlyase subunit HycE -
P5708_RS05625 (1160599) 1160599..1161141 + 543 WP_000493797.1 formate hydrogenlyase subunit HycF -
P5708_RS05630 (1161141) 1161141..1161908 + 768 WP_000067399.1 formate hydrogenlyase subunit HycG -
P5708_RS05635 (1161905) 1161905..1162315 + 411 WP_001291918.1 formate hydrogenlyase assembly protein HycH -
P5708_RS05640 (1162308) 1162308..1162778 + 471 WP_000132959.1 hydrogenase maturation peptidase HycI -
P5708_RS05645 (1162944) 1162944..1163255 + 312 WP_016233494.1 type II toxin-antitoxin system HigB family toxin Toxin
P5708_RS05650 (1163252) 1163252..1163671 + 420 WP_000126294.1 helix-turn-helix domain-containing protein Antitoxin
P5708_RS05655 (1163763) 1163763..1164191 - 429 WP_000536064.1 hypothetical protein -
P5708_RS05660 (1164576) 1164576..1165103 + 528 WP_001078777.1 electron transport protein HydN -
P5708_RS05665 (1165256) 1165256..1167508 + 2253 WP_201478671.1 carbamoyltransferase HypF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12453.25 Da        Isoelectric Point: 9.7075

>T275157 WP_016233494.1 NZ_CP120563:1162944-1163255 [Escherichia coli]
MHIISKAPFEECARKYPNDALALHSLYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNKLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15416.42 Da        Isoelectric Point: 4.4596

>AT275157 WP_000126294.1 NZ_CP120563:1163252-1163671 [Escherichia coli]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References