Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 605296..606095 Replicon chromosome
Accession NZ_CP120563
Organism Escherichia coli strain H22

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag P5708_RS02970 Protein ID WP_000347251.1
Coordinates 605296..605760 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag P5708_RS02975 Protein ID WP_001296435.1
Coordinates 605760..606095 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5708_RS02940 (600297) 600297..600731 - 435 WP_000948837.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
P5708_RS02945 (600749) 600749..601627 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
P5708_RS02950 (601617) 601617..602396 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
P5708_RS02955 (602407) 602407..602880 - 474 WP_001298322.1 PTS N-acetylgalactosamine transporter subunit IIB -
P5708_RS02960 (602903) 602903..604183 - 1281 WP_000681926.1 tagatose-bisphosphate aldolase subunit KbaZ -
P5708_RS02965 (604432) 604432..605241 + 810 WP_089638240.1 aga operon transcriptional regulator AgaR -
P5708_RS02970 (605296) 605296..605760 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
P5708_RS02975 (605760) 605760..606095 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
P5708_RS02980 (606244) 606244..607815 - 1572 WP_001273755.1 galactarate dehydratase -
P5708_RS02985 (608190) 608190..609524 + 1335 WP_000979025.1 galactarate/glucarate/glycerate transporter GarP -
P5708_RS02990 (609540) 609540..610310 + 771 WP_277699696.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T275154 WP_000347251.1 NZ_CP120563:c605760-605296 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT275154 WP_001296435.1 NZ_CP120563:c606095-605760 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References