Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2576838..2577531 Replicon chromosome
Accession NZ_CP120557
Organism Escherichia coli strain B771

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag P5709_RS12750 Protein ID WP_000415584.1
Coordinates 2577235..2577531 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag P5709_RS12745 Protein ID WP_000650107.1
Coordinates 2576838..2577233 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5709_RS12735 (2572702) 2572702..2574960 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
P5709_RS12740 (2575098) 2575098..2576705 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
P5709_RS12745 (2576838) 2576838..2577233 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
P5709_RS12750 (2577235) 2577235..2577531 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
P5709_RS12755 (2577736) 2577736..2578218 - 483 WP_000183505.1 GyrI-like domain-containing protein -
P5709_RS12760 (2578271) 2578271..2578663 - 393 WP_001401138.1 OB fold stress tolerance protein YgiW -
P5709_RS12765 (2578815) 2578815..2579474 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
P5709_RS12770 (2579471) 2579471..2580820 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
P5709_RS12775 (2580866) 2580866..2581198 - 333 WP_000917684.1 DUF2645 family protein -
P5709_RS12780 (2581517) 2581517..2582098 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
P5709_RS12785 (2582129) 2582129..2582443 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T275135 WP_000415584.1 NZ_CP120557:c2577531-2577235 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT275135 WP_000650107.1 NZ_CP120557:c2577233-2576838 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References